Clinical/Translational Research Role of KATP Channels in the Maintenance of Ventricular Fibrillation in Cardiomyopathic Human Hearts
نویسندگان
چکیده
( ERPTransmural for glibenclamide ischemia 4.9 4 ms, P 0.019 versus control ischemia). Conclusions: KATP channel subunit gene expression is heterogeneously altered in the cardiomyopathic human heart. Blockade of KATP channels promotes spontaneous defibrillation in cardiomyopathic human hearts by attenuating the ischemia-dependent spatiotemporal heterogeneity of refractoriness during early VF. (Circ Res.
منابع مشابه
Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts.
RATIONALE Ventricular fibrillation (VF) leads to global ischemia. The modulation of ischemia-dependent pathways may alter the electrophysiological evolution of VF. OBJECTIVE We addressed the hypotheses that there is regional disease-related expression of K(ATP) channels in human cardiomyopathic hearts and that K(ATP) channel blockade promotes spontaneous VF termination by attenuating spatiote...
متن کاملVentricular fibrillation in preconditioned pig hearts: role of KATP
Rioufol, Gilles, Michel Ovize, Joseph Loufoua, Calin Pop, Xavier André-Fouët, and Yves Minaire. Ventricular fibrillation in preconditioned pig hearts: role of KATP 1 channels. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H2804– H2810, 1997.—ATP-dependent potassium (KATP 1 ) channels play a role in the infarct size-limiting effect of preconditioning in pigs. We previously demonstrated that pre...
متن کاملExploring the role and inter-relationship among nitric oxide, opioids, and KATP channels in the signaling pathway underlying remote ischemic preconditioning induced cardioprotection in rats
Objective(s): This study explored the inter-relationship among nitric oxide, opioids, and KATP channels in the signaling pathway underlying remote ischemic preconditioning (RIPC) conferred cardioprotection. Materials and Methods: Blood pressure cuff was placed around the hind limb of the animal and RIPC was performed by 4 cycles of infla...
متن کاملT-type Ca2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts.
Although there is substantial evidence of abnormal Ca2+ homeostasis in heart cells of the cardiomyopathic Syrian hamster (Bio 14.6 strain), the mechanism by which these myocytes become Ca(2+)-overloaded is not known. To elucidate the role of voltage-sensitive Ca2+ channels in the pathogenesis of myopathy, whole-cell Ca2+ currents were measured in myopathic and normal control cardiac myocytes. T...
متن کاملKATP channel opening accelerates and stabilizes rotors in a swine heart model of ventricular fibrillation.
AIMS The mechanisms underlying ventricular fibrillation (VF) are still disputed. Recent studies have highlighted the role of KATP-channels. We hypothesized that, under certain conditions, VF can be driven by stable and epicardially detectable rotors in large hearts. To test our hypothesis, we used a swine model of accelerated VF by opening KATP-channels with cromakalim. METHODS AND RESULTS Op...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011